Inquire question for this cycle: Is there a relationship between depression and facial appearance?

The focus of this round: Why people get depression?

Firstly, let us get know about depression first. Click the video below to have a brief understanding. 

In summary, depress is a mood which will continue for a while or a few hours; MDD(Major depressive disorder, we usually called depression) organized that maintain at least two weeks of low mood that is present across most situations.

Depression is a worldwide mental disease which might occur among both children and elder.[4] Lots of things influence whether a person gets depressed. Some of it is biology[2][1] — things like our genes, brain chemistry, and hormones. Some is the environment, including daylight and seasons, or social and family situations we face. And some is personality, like how we react to life events or the support systems we create for ourselves. [1] 

  • Genes[2][4]
    Research shows that depression runs in families. Some people inherit genes that contribute to depression. However, not everyone who has a family member with depression will also get it. Besides, many people with no family history of depression still get depressed. Hence, genes are one factor, but they aren't the only reason to cause depression.
  • Brain Chemistry[2]
    Chemicals called neurotransmitters to help send messages between nerve cells in the brain. Some neurotransmitters regulate mood. When a person is depressed, these neurotransmitters might be in low supply or not effective enough.


  • Stress, Health, and Hormones[3]
    Things like stress, using alcohol or drugs, and hormone changes also affect the brain's delicate chemistry and mood. [1] Stress is the body’s response to physical or emotional demands. Emotional stress can play a role in causing depression or be a symptom of it. A stressful situation can trigger feelings of depression, and these feelings can make it more difficult to deal with stress. For instance, losing a family member, divorce, losing a job, all might cause depression. 
  • Daylight and Seasons[1]
    Daylight affects how the brain produces melatonin and serotonin. These neurotransmitters help regulate a person's sleep–wake cycles, energy, and mood. When there is less daylight, the brain produces more melatonin. When there is more daylight, the brain makes more serotonin.



    Shorter days and longer hours of darkness in fall and winter may lead the body to have more melatonin and less serotonin. This imbalance is what creates the conditions for depression in some people — a condition known as seasonal affective disorder (SAD). Exposure to light can help improve mood for people affected by SAD.

  • Female Sex Hormones[5]
    It has been widely documented that women suffer from major depression about twice as often as men. Because of the incidence of depressive disorders peaks during women's reproductive years. Women are especially prone to depressive disorders during times when their hormones are in flux, such as around the time of their menstrual period, childbirth, and perimenopause. In addition, a woman's depression risk declines after she goes through menopause.

In summary, there are lost of things might cause a negative mood, but only when this depressed feeling continues for more than a few days, the depression will appear. 



  1. “Why Do People Get Depressed?” Edited by D'Arcy Lyness, KidsHealth, The Nemours Foundation, Aug. 2016, 
  2. “Biology of Depression - Neurotransmitters.” Child Development & Parenting: Infants (0-2),
  4. Some people think they have a clear sense of why they become depressed. Others don't. It might not be easy to figure out. “Common Causes of Depression.” WebMD, WebMD,
  5. Schimelpfening, Nancy. “There Are Many Factors That Could Increase Your Risk of Depression.” Verywell Mind, Dotdash,
Original Post

Hi Ivy!

Great research round! I really liked how you organized it and how easy you made it to read! It's interesting to me that depression is more common in females than males, and a lot of it has to do with having the female reproductive system. Maybe in a future research round you could look into how it affects females and why it makes them more likely. 

Here is a website to help you out:

Good luck!

Hiya Ivy,

I love the way you presented all of your information. It was very to the point and informative. I don't have too much to say, because I don't know much about the idea behind your inquiry. However, maybe looking into how attractive someone is, and how that affects them in work, relationships, communication skills, ext. There seems to be a lot of research on that, and I feel like it might help fill some pieces of your inquiry.

Good luck!

This is such an interesting perspective on depression. I have never realized that female sex hormones and seasons can affect or even cause one susceptibility to depression. It might be great if you could look at other causes of depression that exist but are often overlooked. For example, is there a relationship between age and depression, race and depression. Also, how can we work around these causes? Is there any possible way to reduce the strength of a particular causal aspect?

Here are some links to help you out with your research.


Hoping to see where your research leads you. Good luck!

Hey Ivy! 

This was a really interesting research to read, because I do know about depression, but I did not know there were so many factors to it! You did a really great job in explaining everything clearly with organization and I thought it was a job well done! I really enjoyed learning about neurotransmitters and how they regulate mood, and when one is depressed, they are low in supply. That's something I wasn't aware of! Perhaps in a future round of research, you could talk more about sleep disorders and how they are core symptoms of depression. 

Here's a source you may find useful: 

Again, great job and good luck on your future rounds of research! 

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